Dextrose is a simple sugar that is chemically identical to Glucose. Because dextrose is a simple sugar, the body can quickly use it for energy. The consumption of simple carbohydrates/sugars with Creatine has been shown to increase the uptake of creatine by the muscle and enhance physical performance. At the same time, creatine has also been shown to play an important role in the Glucose uptake by muscle cells. This mechanism is so efficient that many studies have used Creatine supplementation to increase Glucose uptake by the muscles and reduce blood sugar levels in Type 2 Diabetes patients. 

It has also been found that Creatine supplementation increases levels of Glycogen in the muscle. Glycogen is the form in which glucose (sugar) is stored in your muscles and liver. This storage provides energy for your muscles when exercising, and, once the stock is over, muscles are degraded to be used as energy. Higher glycogen stocks will increase endurance and avoid muscle breakdown. Furthermore, after a meal high in glucose, your body will either use that for energy immediately or store it. The storage can be in form of Glycogen or as fatty acids in the fat tissue. As uptake by the muscles rises, less glucose will be transformed into fat to be stored.